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Myonuclei

Myonuclei are nuclei of muscle cells. Muscle cells are created by fusion of many cells and therefore contain 10s-100s of nuclei. The nuclei are positioned throughout the muscle and are known indicators of certain muscle diseases.

Positioning and Scaling of Nuclei in Muscle Cells

myonuclei Collaboration with the groups of
    Mary Baylies, Sloan Kettering Cancer Center
    Alex Mogilner, New York University

Questions of Interest
    How are nuclei positioned within the muscle cells? Which forces are responsible for the correct positioning of the nuclei? What determined the size and output of the nuclei and is there a relation between the position and the size of individual nuclei?

Mathematical Methods
  •  Interacting particle models
  •  Stochastic agent-based models
  •  Data analysis of fluorescence microscopy images

Related publications can be found on the publication page.

myonuclei